Table 5. Multivariate Cox analysis of overall survival using the IMDC prognostic factors.
| Parameter | Parameter estimate±s.e. | Hazard ratio | 95% CI | P-value |
|---|---|---|---|---|
| ECOG PS >1 | 0.79±0.05 | 2.20 | 1.98–2.44 | <0.0001 |
| Time from diagnosis to treatment <1 year | 0.28±0.04 | 1.32 | 1.21–1.44 | <0.0001 |
| Haemoglobin < LLN | 0.61±0.05 | 1.84 | 1.68–2.01 | <0.0001 |
| Calcium>ULN | 0.34±0.06 | 1.41 | 1.25–1.59 | <0.0001 |
| Neutrophil count > ULN | 0.71±0.05 | 2.03 | 1.83–2.25 | <0.0001 |
| Platelet count > ULN | 0.31±0.05 | 1.36 | 1.23–1.50 | <0.0001 |
Abbreviations: CI=confidence interval; ECOG PS=Eastern Cooperative Oncology Group performance status; IMDC=International Metastatic Renal-Cell Carcinoma Database Consortium; LLN=lower limit of normal; s.e.=standard error; ULN=upper limit of normal.