Table 6.

Univariate and multivariate analyses of factors predicting recurrence-free survival of penicilliosis among HIV-negative patients

Factor	Univariate			Multivariate
	HR	95 % CI	P	HR	95 % CI	P
Age > 60 or < 3 years	0.700	0.274–1.792	0.457
Underlying diseases	0.228	0.064–0.813	0.014*	0.289	0.074-1.132	0.075
Fever	0.300	0.065–1.378	0.122
Lymphadenopathy	2.074	0.601–7.155	0.249
Hepatomegaly	0.374	0.118–1.185	0.095
Splenomegaly	0.606	0.217–1.697	0.341
Cutaneous lesions	0.575	0.225–1.471	0.248
Cough	6.568	0.861–50.100	0.069
Dyspnoea	1.265	0.479–3.344	0.635
Anaemia	1.525	0.439–5.303	0.507
Osteolysis	0.581	0.209–1.618	0.299
Thoracalgia	1.204	0.453–3.200	0.710
Bloody stools/diarrhoea	1.122	0.326–3.869	0.855
Duration of diagnosis	1.026	0.405–2.597	0.957
WBC > 10*109/L	0.628	0.181–2.177	0.463
Neutrophils > 6.3*109/L	0.573	0.205–1.604	0.289
Lymphocytes < 1.10*109/L	2.093	0.730–6.004	0.169
Haemoglobin < 130 g/L	1.082	0.410–2.855	0.874
ALT > 45U/L	2.941	0.608–14.230	0.180
ALB < 55U/L	1.274	0.288–5.627	0.749
CD4 < 410/ul	1.003	0.998–1.008	0.289
CD8 < 190 /ul	0.994	0.985–1.002	0.146
CD4% < 31.98 %	3.033	1.186–7.754	0.015*	1.224	0.305–4.921	0.775
CD8% < 20.70 %	0.654	0.256–1.121	0.374
T cell% < 64.2 %	2.963	1.146–7.659	0.019*	1.950	0.504–7.539	0.333
IgG < 7 g/L	0.800	0.181–3.536	0.769
Chest imaging	0.708	0.251–1.999	0.515

Patients with Penicillium marneffei infection were divided into two groups; Group D included patients with underlying disease, and Group ND included patients without underlying disease

ALB serum albumin, ALT alanine aminotransferase, CI confidence interval, HR hazard ratio, WBC white blood cell, CD4 CD4 T cell count, CD8 CD8 T cell count, CD4% CD4 cell percentage, CD8% CD8 cell percentage, T cell% T lymphocyte cell percentage, IgG serum immunoglobulin G. *P < 0.05