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. 2015 Nov 16;15:159. doi: 10.1186/s12876-015-0380-5

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© Liu et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Effects of sorafenib and/or GdCl3 blockage on in vivo expression of proinflammatory cytokines in liver fibrosis. a CD68 immunohistochemistry (magnification X 400, n = 4). b Levels of mRNA encoded by genes encoding proinflammatory cytokines in rats with DMN-induced fibrosis (n = 6). c The Expression of CD68, TNF-α, IL1β, CCL2 was analyzed using western blot (n = 6). Control, vehicle alone; 4 W, DMN for 4 weeks; S, DMN for 4 weeks plus sorafenib for 2 weeks; G, DMN for 4 weeks plus GdCl3 for 2 weeks; S + G, DMN for 4 weeks plus sorafenib and GdCl3 for 2 weeks. Results reported as mean ± S.D. *p < 0.05; **p < 0.01 vs 4 W