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. 2015 Nov 16;15:159. doi: 10.1186/s12876-015-0380-5

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© Liu et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Effects of sorafenib and/or GdCl3 on in vivo expression of pro-fibrotic factors in rat liver fibrosis. a α-SMA immunohistochemistry (magnification X 200, n = 4). b Levels of mRNA encoded by genes encoding factors associated with fibrosis sis (n = 6). c the Expression of α-SMA, TIMP1, TGF-β1, COL1 was analyzed using western blot (n = 6). Control, vehicle alone; 4 W, DMN for 4 weeks; S, DMN for 4 weeks plus sorafenib for 2 weeks; G, DMN for 4 weeks plus GdCl3 for 2 weeks; S + G, DMN for 4 weeks plus sorafenib and GdCl3 for 2 weeks. Results reported as mean ± S.D. * p < 0.05; ** p < 0.01 vs 4 W