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. 2015 Nov 16;16:953. doi: 10.1186/s12864-015-2143-7

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© Kuley et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Functional COG-categories of differentially regulated C. burnetii genes under in vivo and in vitro culture models. Functional categories of regulated genes of the 602 strain under in vivo and cell-free culture compared with cell culture model. The up-regulated and down-regulated genes are shown on the right and left side of the y-axis respectively. Largest group of regulated genes in all culture models belonged to the unknown function category (S). Large number of up-regulated genes under in vivo conditions belonged to the metabolism group such as coenzyme, carbohydrate, amino acid and lipid transport and metabolism (HGEI). Whereas, the largest number of up-regulated genes in cell-free culture compared to cell culture belonged to the protein synthesis group (O)