Table 1.
Significantly regulated (KEGG) Pathways in different culture models of C. burnetii
| Pathway ID | Pathway | m vs. cc | p1 vs cc | p2 vs. cc | cf vs cc |
|---|---|---|---|---|---|
| Metabolic pathways | |||||
| cbu00230 | Purine metabolism | 5.20E-18* | 2.00E-01 | 5.40E-06* | 1.10E-12* |
| cbu00010 | Glycolysis/Gluconeogenesis | 1.00E-13* | 3.80E-03* | 1.50E-07* | 1.50E-07* |
| cbu00190 | Oxidative phosphorylation | 3.10E-10* | 2.40E-01 | 1.90E-02* | 1.30E-01 |
| cbu00240 | Pyrimidine metabolism | 5.20E-06* | 9.80E-03* | 1.80E-08* | 5.60E-05* |
| cbu00564 | Glycerophospholipid metabolism | 1.80E-05* | 6.30E-02 | 6.00E-02 | 6.80E-02 |
| cbu00020 | Citrate cycle (TCA cycle) | 9.20E-04* | - | 3.40E-02* | 5.30E-02 |
| cbu00071 | Fatty acid metabolism | 3.10E-03* | - | - | - |
| cbu00061 | Fatty acid biosynthesis | 3.20E-03* | 1.40E-02* | 7.40E-02 | 7.90E-02 |
| Biosynthesis of secondary metabolites | |||||
| cbu00900 | Terpenoid backbone biosynthesis | 2.80E-05* | - | - | - |
| cbu00780 | Biotin metabolism | 1.00E-04* | 1.00E-03* | 2.30E-03* | 2.40E-06* |
| cbu00730 | Thiamine metabolism | 6.10E-04* | 7.90E-03* | 9.80E-03* | 1.30E-05* |
| Biosynthesis of amino acids | |||||
| cbu00400 | Aromatic amino acids biosynthesis | 8.40E-08* | - | - | - |
| cbu00250 | Alanine, aspartate and glutamate metabolism | 3.40E-05* | - | 2.30E-02* | 1.20E-03* |
| cbu00260 | Glycine, serine and threonine metabolism | 2.20E-04* | 1.60E-04* | 2.30E-06* | 1.10E-04* |
| Virulence | |||||
| cbu00540 | Lipopolysaccharide biosynthesis | 5.40E-10* | 2.80E-04* | 3.70E-05* | 1.90E-04* |
| cbu03070 | Bacterial secretion system | 7.40E-08* | 6.90E-02 | - | 1.30E-03* |
| Repair mechanisms | |||||
| cbu03430 | Mismatch repair | 7.90E-13* | - | 3.60E-06* | 1.50E-17* |
| cbu03410 | Base excision repair | 1.00E-07* | - | 3.40E-02* | 2.50E-05* |
| cbu03420 | Nucleotide excision repair | 8.00E-07* | - | - | 4.50E-02* |
| Others | |||||
| cbu00550 | Peptidoglycan biosynthesis | 4.00E-13* | - | - | 3.30E-03* |
| cbu02010 | ABC transporters | 1.00E-04* | - | 4.00E-02* | 1.10E-03* |
| cbu02020 | Two-component system | 3.50E-03* | - | - | - |
The P value (adjusted by Benjamini-Hochberg method) of regulated pathway is shown for each comparison of 602 strain. Significant pathways (p < 0.05) are depicted with *. In vivo (m = Mice spleen), cell culture (cc), cell-free adapting phase passage 1 (p1), cell-free adapting phase passage 2 (p2), cell-free culture model (cf)