Table 2. Expression of phosphoproteins in all samples, RAS-mutated samples and RAS wild-type samples.
| All* | RAS mutated* | RAS wild type* | P | |
|---|---|---|---|---|
| pAKT | 104.01; 98.5 (86.04; 124.55) | 110.79; 109.46 (93.31; 126.27) | 99.49; 92.83 (82.10; 122.07) | 0.0246 |
| pEGFR | 139.35; 109.39 (86.69; 141.04) | 174.69; 105.38 (88.58; 146.54) | 115.80; 110.11 (85.16; 139.13) | 0.9355 |
| pERK1/2 | 245.73; 138.98 (101.59; 263.85) | 350.22; 178.23 (137.87; 395.01) | 176.07; 113.83 (92.04; 169.58) | 0.0004 |
| pGSK3 | 133.03; 101.05 (66.38; 183.82) | 135.62; 97.79 (66.38; 168.41) | 131.30; 105.88 (65.32; 184.71) | 0.7676 |
| pIGFR | 83.65; 74.83 (64.29; 96.68) | 83.52; 70.81 (63.89; 91.62) | 83.74; 77.13 (64.70; 101.09) | 0.4024 |
| pMEK1 | 272.19; 131.82 (80.42; 280.74) | 411.25; 209.52 (87.89; 402.14) | 179.48; 104.09 (77.70; 201.28) | 0.0110 |
| pP70S6K | 123.31; 112.49 (89.14; 135.21) | 131.39; 124.47 (93.58; 136.83) | 117.93; 105.24 (85.00; 135.21) | 0.1690 |
| pP90SRK | 74.37; 75.61 (49.71; 95.38) | 81.03; 80.27 (48.73; 101.78) | 69.93; 71.78 (50.11; 88.26) | 0.1303 |
Expression of pAKT, pERK1/2 and pMEK1 is significantly lower in RAS wild-type patients.
*Mean; median (lower quartile; upper quartile).