Table 3. Expression of phoshoproteins and response rate.
|
(a) | |||||
|---|---|---|---|---|---|
| pProt | AUC and 95% CI | Thresholda | CR or PR | P-value | OR and 95% CI |
| pAKT | 0.588 (0.436; 0.74) | <120 | 36.36% (16) | 0.0258 | 1 |
| ⩾120 | 68.75% (11) | 3.85 (1.13; 13.07) | |||
| pEGFR | 0.634 (0.491; 0.776) | <100 | 25.00% (5) | 0.0277 | 1 |
| ⩾100 | 55.00% (22) | 3.67 (1.12; 12.03) | |||
| pERK1/2 | 0.497 (0.348; 0.646) | <110 | 38.45% (10) | 0.373 | 1 |
| ⩾110 | 50.00% (17) | 1.60 (0.57; 4.51) | |||
| pGSK3 | 0.504 (0.355; 0.653) | <130 | 38.24% (13) | 0.228 | 1 |
| ⩾130 | 53.85% (14) | 1.88 (0.67; 5.31) | |||
| pIGFR | 0.513 (0.365; 0.662) | <60 | 33.33% (3) | 0.445 | 1 |
| ⩾60 | 47.06% (24) | 1.78 (0.40; 7.89) | |||
| pMEK1 | 0.497 (0.348; 0.646) | <100 | 38.46% (10) | 0.373 | 1 |
| ⩾100 | 50.00% (17) | 1.60 (0.57; 4.51) | |||
| pP70S6K | 0.585 (0.439; 0.731) | <105 | 36.67% (11) | 0.194 | 1 |
| ⩾105 | 53.33% (16) | 1.97 (0.70; 5.54) | |||
| pP90SRK | 0.577 (0.43; 0.723) | <70 | 35.71% (10) | 0.176 | 1 |
| ⩾70 | 53.13% (17) | 2.04 (0.72; 5.77) | |||
|
(b) | |||||
|
Multivariate | |||||
| pProt | OR and 95% CI | ||||
| pAKT | 1 | ||||
| 3.70 (1.04;13.18) | |||||
| pEGFR | 1 | ||||
| 3.53 (1.03;12.11) | |||||
Abbreviations: AUC=area under the receiver operating characteristic; CI=confidence interval; CR=complete response; OR=odds ratio; PR=partial response.
(a) Patients with expression of pAKT over 120 and pEGFR over 100 achieved significantly better response rate. (b) These two phosphoproteins remained statistically significant in multivariate analysis to predict response after bootstrap validation. Statistically significant p-values are presented in bold.
a
Optimal threshold according to the Youden index.