Table 2. Univariate and multivariate Cox proportional hazards regression analysis for OS.

	Univariate	Multivariatea			Multivariateb
Variables	P-values	HR	95% CI	P-values	HR	95% CI	P-values
Age	0.185
Sex	0.236
TNM stage	<0.001			<0.001			<0.001
I		Reference			Reference
II		1.331	0.500–3.541	0.567	1.277	0.472–3.458	0.630
III		2.222	1.232–4.008	0.008	2.348	1.302–4.232	0.005
IV		24.483	5.197–115.332	<0.001	14.644	4.651–46.106	<0.001
Fuhrman grade	<0.001			0.017			0.023
1		Reference			Reference
2		1.215	0.401–3.686	0.731	1.374	0.455–4.150	0.573
3		1.263	0.401–3.983	0.690	1.483	0.477–4.613	0.496
4		3.267	1.041–10.253	0.042	3.519	1.133–10.931	0.030
Tumour size, cm	<0.001			0.428			0.540
<5		Reference			Reference
⩾5		1.255	0.716–2.200		1.192	0.680–2.091
Tumour necrosis	<0.001			0.096			0.199
Absent		Reference			Reference
Present		1.621	0.918–2.862		1.449	0.823–2.550
LVI	<0.001			<0.001			<0.001
Absent		Reference			Reference
Present		2.959	1.657–5.286		3.033	1.699–5.414
Albuminc	<0.001	0.909	0.840–0.985	0.019
Haemoglobinc	<0.001	0.993	0.977–1.009	0.406
LMRc	<0.001	0.839	0.705–0.998	0.047
PLRc	<0.001	0.997	0.994–1.001	0.138
NLRc	<0.001	0.971	0.838–1.124	0.691
SIS	<0.001						0.001
0					Reference
1					2.109	1.020–4.362	0.044
2					4.149	1.980–8.695	<0.001

Abbreviations: CI=confidence interval; HR=hazard ratio; LMR=lymphocyte to monocyte ratio; LVI=lymphovascular invasion; NLR=neutrophil to lymphocyte ratio; OS=overall survival; PLR=platelet to lymphocyte ratio; SIS=systemic inflammation score.

^aAdjustment for all variables listed in the table, except for age, sex and SIS.

^bAdjustment for all variables listed in the table, except for age, sex, albumin, haemoglobin, LMR, PLR and NLR.

^cAnalysed as a continuous variable.