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. 2015 Jul 14;113(4):645–652. doi: 10.1038/bjc.2015.246

Figure 3.

Figure 3

Microvascular blood flow for deep (A) and superficial (B) tumours. Among the deep tumours (A), there were significant increases in the microvascular blood flow from before to 30 min after TM-ILP for both tumour tissue (P=0.007) and muscle tissue (P=0.013). Between 30 min and 6 weeks after TM-ILP, there were again significant decreases for tumour tissue (P=0.007) and muscle tissue (P=0.004). Although both flow rates remained elevated, no significant changes were observed because of greater within-group variance. In the superficial tumour group (B), there was a significantly higher flow in tumour tissue than in muscle tissue both before (P=0.004) and 30 min after TM-ILP (P=0.009). This difference in flow remained highly significant at 1 week (P=0.034) and 2 weeks (P=0.012) after TM-ILP, but it was not observed 6 weeks after TM-ILP, at which point the flow rates were similarly low. The superficial tumour group (B) also exhibited time-dependent changes. There was a significant increase in the flow rate from before TM-ILP to 30 min after TM-ILP for both tumour (P=0.038) and muscle tissues (P=0.002). The flow rate remained elevated for 2 weeks after TM-ILP. Between 2 and 6 weeks after TM-ILP, the flow rate for tumour tissue decreased significantly (P=0.011).