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. 2015 Nov 16;13:96. doi: 10.1186/s12915-015-0205-6

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© Lu et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — A dynamic model for substrate degradation. a The components of the model. A: free APC/C^Cdc20, S: free substrate, AS: APC/C^Cdc20-substrate complex, k _a: association rate constant, k _d: dissociation rate constant, k _c: catalytic rate constant, e: degradation rate constant, p _A: accumulation rate of active APC/C^Cdc20. See Additional file 1: Figure S4 for equations. b An example of a degradation profile of a substrate at one parameter set. APC/C anaphase-promoting complex/cyclosome