Table 2.
Characteristics of the studies and odds ratio OR (95%CI) for studies reporting 24 h median intra-gastric pH as outcomes
| Reference | Dose (mg) | Duration (Days) | Mean Age (Years) | Sex (Male %) | Outcome measures as reported in the studies included in our analysis | |||
|---|---|---|---|---|---|---|---|---|
| Odds of 24 h median intra-gastric pH > 4 OR | Median intra-gastric pH within 24 h post dose (pH) | Mean time pH > 4 within 24 h post dose (h) | % time duration of 24 h with intra-gastric pH > 4 (%) | |||||
| 30 | O:40 | 1 | 31.7 | 46 | 1.00 | 4.5 (4.36- 4.64) | 17.8 (17.4-18.5) | 62.0 (59.0-65.0) |
| E: 40 | 1 | 31.7 | 46 | 2.08 (1.10, 3.96) | 4.8 (4.64- 4.92) | 19.2 (18.6-19.75) | 68.4 (65.4-71.4) | |
| 31 | O:20 | 1 | 58 | 47 | NR | 6.4 (6.32- 6.42) | NR | NR |
| E: 20 | 1 | 59 | 47 | NR | 6.4 (6.30- 6.52) | NR | NR | |
| 32 | O:20 | 5 | 45 | 42 | 1.00 | 3.6 (3.2- 3.9) | 10.5 (8.8-12.2) | 43.7 (36.7-50.7) |
| E: 20 | 5 | 45 | 42 | 1.23 (0.63, 2.38) | 4.1 (3.8- 4.5) | 12.7 (11.0-14.4) | 53.0 (46.0-60.0) | |
| 33 | O:20 | 7 | 21.7 | 75 | NR | 5.4 (3.5 - 6.8) | 22.6 (20.3–24)] | 79.2 (40.0-90.2) |
| E: 20 | 7 | 21.7 | 75 | NR | 5.4 (3.5–6.8) | 21.1 (17.2–23.8) | 81.0 (60.0-90.0) | |
| 34 | O:20 | 5 | 18-6 | 46 | 1.00 | 3.5 (1.6-5.3) | 10.4 (3.0–20.2) | 44.0 (12.4-83.9) |
| E:20 | 5 | 18-6 | 46 | 1.42 (0.56, 3.63) | 3.9 (1.9-5.1) | 11.3 (3.7–18.0) | 48.0 (15.5-75.3) | |
| Overall effect of all studies combined: | O | 1.00 | 4.39 (3.36, 5.73) | 15.24 (12.13, 19.14) | 52.01 (39.52, 68.44) | |||
| E | 1.57 (1.04, 2.38) (p = 0.03)* | 4.69 (3.79, 5.81) (p = 0.67) | 16.43 (13.72, 19.66) (p = 0.55) | 60.10 (48.58, 74.34) (p = 0.40) | ||||
* Statistical significance of difference from referance (p < 0.05), NR- Data not reported