Table 1.
Summary of all mice challenged with sporozoites
| Parasite line | Sporozoite dose injected i.v. | Infected mice/total mice | Sporozoite-induced breakthrough parasites |
|---|---|---|---|
| WT | 10,000 | 4/4 | |
| WT | 10,000 | 4/4 | |
| WT | 10,000 | 4/4 | |
| SpZFN | 10,000 | 0/4 | |
| SpZFN | 25,000 | 1/10 | SpZFN SI 1 |
| SpZFN | 25,000 | 3/9 | SPZFN SI 2–4 |
| SpZFN | 500,000 | 4/4 | SpZFN SI 5–8 |
| SpZFN | 25,000 | 3/16 | SpZFN SI 9–11 |
| LsZFN | 10,000 | 4/4 | LsZFN SI 1–4 |
| Sp2ZFN | 25,000 | 0/4 | |
| Sp2ZFN | 10,000 | 0/4 | |
| Ls2ZFN | 25,000 | 5/12 | Ls2ZFN SI 1–5 |
| Ls2ZFN | 250,000 | 4/8 | LsZFN SI 6–9 |
| Ls2ZFN | 1,000,000 | 2/4 | |
| Uis4ZFN | 25,000 | 0/8 | |
| Uis4ZFN | 250,000 | 3/8 | Uis4ZFN SI 1–3 |
| TrapZFN | 25,000 | 2/4 | TrapZFN SI 1–2 |
| TrapZFN | 250,000 | 0/4 | |
| SpZFN SI 2 | 10,000 | 8/8 |
SI sporozoite induced