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. 2015 Nov 17;5:16641. doi: 10.1038/srep16641

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Possible hydrogen bonds are indicated by dashed lines. (A) Adenosine (ADO). (B) 3′-Keto-aristeromycin (3KA). (C) Noraristeromycin (NRN). (D) Ribavirin (RBV). (E) A superposition of the ADO (transparent pink) and RBV (yellow) complexes. The flipped-out conformation of His301 observed in the ADO and RBV complexes is indicated as H301_out.