Table 4. Summary of derived blood and sputum eosinophil parameters by treatment group.

Parameter (unit)	Summary statistics	Mepolizumab dose
		SC 12.5 mg n = 21	SC 125 mg n = 15	SC 250 mg n = 23	IV 75 mg n = 11
Blood eosinophils
AUECeos(0–day 84) (GI.d/L)	n	20	14	21	11
	Geo mean	21.551	7.198	6.381	7.556
	95% CI	15.486 – 29.991	5.290 – 9.796	4.915 – 8.284	5.459 – 10.459
Proportional inhibition AUECeos(0–day 84)	n	20	14	21	11
	Geo mean	0.396	0.743	0.818	0.687
	95% CI	0.263 – 0.596	0.679 – 0.813	0.780 – 0.857	0.602 – 0.784
wmeaneos(0–day 84) (GI/L)	n	21	15	23	11
	Geo mean	0.251	0.090	0.083	0.090
	95% CI	0.183 – 0.345	0.066 – 0.121	0.063 – 0.109	0.065 – 0.125
Maxeos (GI/L)	n	21	15	23	11
	Geo mean	0.203	0.113	0.082	0.141
	95% CI	0.124 – 0.331	0.079 – 0.162	0.057 – 0.119	0.085 – 0.233
tmaxeos (Days)	n	21	15	23	11
	Arithmetic mean	50.0	49.4	47.0	58.8
	95% CI	34.6 – 65.5	34.0 – 64.8	32.0 – 62.0	42.0 – 75.6
Subjects achieving ≥ 50% repletion	n (%)	8 (38)	1 (7)	2 (9)	1 (9)
Sputum eosinophils
Proportional Inhibition AUECspeos(0–day 84)	n	10	5	13	7
	Geo mean	0.315	0.627	0.693	0.690
	95% CI	0.125 – 0.793	0.377 – 1.045	0.562 – 0.856	0.579 – 0.821
wmeanspeos(0–day 84) (%)	n	16	8	13	7
	Geo mean	7.734	1.368	2.551	1.938
	95% CI	3.914 – 15.283	0.772 – 2.424	1.075 – 6.054	0.580 – 6.473
Maxspeos (%)	n	15	6	13	7
	Geo mean	0.228	0.025	0.042	0.122
	95% CI	0.112 – 0.465	0.006 – 0.101	0.016 – 0.110	0.032 – 0.466
tmaxspeos (Days)	n	15	6	13	7
	Arithmetic mean	33.6	43.2	50.6	27.0
	95% CI	20.7 – 46.5	14.4 – 72.0	33.2 – 68.0	6.7 – 47.3

AUEC_{eos(0–day 84)} = area under the absolute blood eosinophil-time curve to day 84 determined using the linear trapezoidal rule, for subset of subjects with blood eosinophil data to day 84; proportional inhibition AUEC_{eos(0–day 84)} = area above the absolute blood eosinophil-time curve to day 84 as a proportion of the total area under the baseline blood eosinophil level to day 84, for subset of subjects with blood eosinophil data to day 84; wmean_{eos(0–day 84)} = weighted mean absolute blood eosinophil levels (day 0 – 84 or last day with available eosinophil data prior to day 84; Max_eos = maximum reduction from baseline in blood eosinophils (between day 0 and last quantifiable measurement); tmax_eos = time to first occurrence of maximum reduction from baseline in blood eosinophil levels (between day 0 and last quantifiable measurement); proportional inhibition AUEC_{speos(0–day 84)} = area above the percent sputum eosinophil-time curve to day 84 as a proportion of the total area under the baseline percent sputum eosinophil level to day 84; wmean_{speos(0–day 84)} = weighted mean percent sputum eosinophil levels (day 0 – 84 or last day with available eosinophil data prior to day 84; Max_speos = maximum reduction from baseline in percent sputum eosinophils; tmax_speos = time to maximum reduction in percent sputum eosinophil levels; Geo = geometric; CI = confidence interval.