Table 1. Patient characteristics.
| mKRAS | mEGFR | WT KRAS/EGFR | P value | |
|---|---|---|---|---|
| Total N | 265 (31.5) | 103 (12.2) | 473 (56.3) | |
| Male | 174 (65.7) | 29 (28.4) | 318 (67.2) | <0.0001 |
| Mean age (y) | 63.26±10.07 | 63.67±14.23 | 63.39±11.65 | 0.95 |
| pT | 0.002 | |||
| 1 | 59 (22.3) | 22 (21.4) | 132 (27.9) | |
| 2 | 129 (48.7) | 49 (47.6) | 173 (36.6) | |
| 3 | 66 (24.9) | 30 (29.1) | 125 (26.4) | |
| 4 | 11 (4.2) | 2 (1.9) | 43 (9.1) | |
| pN+ | 216 (81.5) | 32 (31.1) | 177 (37.4) | <0.0001 |
| pN | <0.0001 | |||
| pN0 | 49 (18.5) | 71 (68.9) | 296 (62.6) | |
| pN1 | 156 (58.9) | 15 (14.6) | 84 (17.8) | |
| pN2 | 60 (22.6) | 17 (16.5) | 93 (19.7) | |
| Skip N | 9 (15) | 9 (60) | 0 | <0.0001 |
| Microscopic N | 20 (9.3) | 17 (53.1) | 0 | <0.0001 |
| Number of N2 stations | 0.004 | |||
| 1 | 37 (61.7) | 14 (82.4) | 78 (84.8) | |
| 2 | 23 (38.3) | 3 (17.6) | 14 (15.2) | |
| Smoking | <0.0001 | |||
| Never | 36 (13.6) | 91 (88.3) | 43 (9.1) | |
| Past | 101 (38.1) | 6 (5.8) | 210 (44.4) | |
| Current | 128 (48.3) | 6 (5.8) | 220 (46.5) | |
| R0 resection | 263 (99.2) | 101 (98.1) | 464 (98.1) | 0.45 |
| Angioinvasion | 155 (58.5) | 17 (16.5) | 157 (33.2) | <0.0001 |
| Neo-adjuvant treatment | 97 (36.6) | 34 (33) | 198 (41.9) | 0.15 |
| Type of neo-adjuvant treatment | 0.15 | |||
| Chemo. | 74 (76.3) | 23 (67.6) | 160 (80.8) | |
| RT chemo. | 23 (23.7) | 11 (32.4) | 38 (19.2) | |
| Type of resection | 0.13 | |||
| Lobectomy | 243 (91.7) | 9 (88.3) | 403 (85.2) | |
| Bi-lobectomy | 12 (4.5) | 4 (3.9) | 32 (6.8) | |
| Pneumonectomy | 1 (0.4) | 2 (1.9) | 14 (3) | |
| Segmentectomy | 9 (3.4) | 6 (5.8) | 24 (5.1) | |
| Adjuvant treatment | 217 (81.9) | 34 (33) | 183 (38.7) | <0.0001 |
| Type of adjuvant treatment | <0.0001 | |||
| RT | 1 (0.5) | 2 (5.9) | 6 (3.3) | |
| Chemo. | 194 (89.4) | 32 (94.1) | 149 (81.4) | |
| RT chemo. | 22 (10.1) | 0 | 28 (15.3) | |
| CCI | 0.45 | |||
| 0 | 22 (8.3) | 13 (12.6) | 54 (11.4) | |
| 1 | 99 (37.4) | 46 (44.7) | 171 (36.2) | |
| 2 | 72 (27.2) | 21 (20.4) | 120 (25.4) | |
| 3 | 72 (27.2) | 23 (22.3) | 128 (27.1) |
Abbreviations: chemo.=chemotherapy; CCI=Charlson comorbidity index; RT=radiation therapy; y=years.
Data are given as n (%).