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. 2015 Oct 8;113(8):1186–1196. doi: 10.1038/bjc.2015.273

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Copyright © 2015 Cancer Research UK

From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Effects of FOXO1 silencing on orthotoipic tumour formation and metastasis in a mice model. GC cells (SNU-638 and MKN45) expressing control shRNA (shCtrl) or FOXO1 shRNA (shFOXO1) were orthotopically xenografted into the stomach (submucosa) and were grown for 60 days. (A) Numbers of mice showing primary tumour formation, as well as site and incidence of metastasis are shown. (B–E) Representative photographs showing the macroscopic appearances of the stomach (B and C), liver (D) and pereitoneum (E) from animals implanted with either shCtrl transfectants (left) or shFOXO1 transfectants (right). (F) Histological appearance of organs showing primary (stomach) or metastatic (vein, lymph node, oesophagus, liver and pancreas) tumours. Arrows indicate primary or metastatic foci ( × 200 magnification).