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. 2015 Sep 15;113(8):1148–1157. doi: 10.1038/bjc.2015.322

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Copyright © 2015 Cancer Research UK

From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Metabolic fingerprints associated with mRCC targeted therapies. O-PLS loadings plots are represented for arm A: (A) W0 vs W2, and (B) W0 vs W5–6, and for arm C: (C) W0 vs W5–6. Statistically significant individual signals correspond to the coloured spectral regions. Highlighted candidate markers are: (1) acetate, (2) acetoacetate, (3) acetone, (4) alanine, (5) cholesterol (C18, C26, C27), (6) ethanol, (7) glucose, (8) glutamine, (9) glycerol, (10) glycerol backbone of pglys and tags, (11) glycine, (12) N-acetylglycoprotein (NAC1), (13) NAC2, (14) isoleucine, (15) leucine, (16) fatty acids (mainly LDL), (17) fatty acids (mainly VLDL), (18) fatty acids and (19) valine. LDL=low-density lipoprotein; VLDL=very low-density lipoprotein; PGLYs=phosphoglycerides; TAGs=triglycerides.