Figure 2.

Effects of integrin α6 knockdown on cell adhesion and migration-related genes of human thymic epithelium. The figure shows extracellular matrix and chemokine ligand genes up- and downregulated after integrin α6 (ITGA6) knockdown by small interference RNA (siRNA) strategy. Gene expression was defined using PCR arrays, comparing ITGA6 siRNA-treated thymic epithelial cells (n = 5) with control siRNA cells (n = 5). Bar colors indicate different group of genes (LM chains and FN in green, integrin sub-unities in purple, chemokines in orange and cytokines in blue). Right bars are upregulated genes and left bars are downregulated genes, both showed in percentage. Two-tailed unpaired Student’s t-test was applied, and the differences showed were all significant. Data derived from Ref. (72).