Table 2.
Association of cholesterol efflux capacity with incident coronary heart disease events
| Bottom tertile | Middle tertile | Top tertile* | Per-SD increase | |
|---|---|---|---|---|
| Not adjusted | 1·00 (0·86–1·16) | 0·78 (0·67–0·9) | 0·58 (0·48–0·71) | 0·70 (0·64–0·78) |
| Adjusted for age, sex, batch number | 1·00 (0·86–1·17) | 0·79 (0·68–0·92) | 0·56 (0·46–0·68) | 0·70 (0·62–0·78) |
| Plus history of diabetes | 1·00 (0·85–1·17) | 0·83 (0·71–0·96) | 0·60 (0·49–0·73) | 0·75 (0·67–0·83) |
| Plus history of hypertension | 1·00 (0·85–1·18) | 0·82 (0·70–0·96) | 0·59 (0·48–0·72) | 0·75 (0·67–0·83) |
| Plus cigarette use | 1·00 (0·85–1·18) | 0·82 (0·71–0·96) | 0·59 (0·48–0·73) | 0·76 (0·68–0·84) |
| Plus alcohol use | 1·00 (0·85–1·18) | 0·84 (0·72–0·98) | 0·61 (0·50–0·75) | 0·76 (0·68–0·84) |
| Plus waist:hip ratio and BMI | 1·00 (0·85–1·18) | 0·84 (0·72–0·98) | 0·62 (0·51–0·77) | 0·80 (0·71–0·90) |
| Plus LDL cholesterol | 1·00 (0·85–1·18) | 0·83 (0·71–0·96) | 0·59 (0·48–0·73) | 0·78 (0·70–0·87) |
| Plus log-triglycerides | 1·00 (0·85–1·18) | 0·82 (0·70–0·96) | 0·58 (0·47–0·71) | 0·78 (0·70–0·87) |
| Plus HDL cholesterol | 1·00 (0·83–1·20) | 0·84 (0·73–0·97) | 0·64 (0·51–0·80) | 0·80 (0·70–0·90) |
Data are odds ratio (95% CI). Mean cholesterol efflux capacity was 0·83 (SD 0·09) in the bottom tertile, 1·13 (SD 0·09) in the middle tertile, and 1·40 (SD 0·09) in the top tertile. We calculated odds ratios for coronary heart disease by unconditional logistic regression analyses. The total number of participants was the same for all the models. We estimated 95% CIs from floating absolute variances that represent the amount of information underlying each group (including the reference group).20
*
For trend, p<0·0001.