Table 1. Patient characteristics.
| Characteristics | Normal (n = 20) | LSIL (n = 52) | HSIL (n = 92) | Cancer (n = 5) | Total (n = 169) | Pvalue | Q value |
|---|---|---|---|---|---|---|---|
| Age, years | |||||||
| Mean (SD, range) | 31 (5.19, 24–43) | 32 (5.66, 23–45) | 30 (4.65, 25–43) | 34 (5.29, 27–41) | 31 (5.08, 23–45) | ||
| Ethnicity, n/N (%) | 0.04 | 0.20 | |||||
| Caucasian | 12/20 (60) | 46/52 (88) | 78/92 (85) | 4/5 (80) | 140/169 (83) | ||
| Asian | 2/20 (10) | 3/52 (6) | 9/92 (10) | 0/5 (0) | 14/169 (8) | ||
| Black | 6/20 (30) | 3/52 (6) | 5/92 (5) | 1/5 (20) | 15/169 (9) | ||
| Parity, n/N (%) | 0.83 | 1.00 | |||||
| Nulliparous | 16/20 (80) | 38/52 (73) | 68/92 (74) | 3/5 (60) | 125/169 (74) | ||
| Parous | 4/20 (20) | 14/52 (27) | 24/92 (26) | 2/5 (40) | 44/169 (26) | ||
| Smoking status, n/N (%) | 0.07 | 0.37 | |||||
| Current smoker | 1/20 (5) | 11/52 (21) | 28/92 (30) | 1/5 (20) | 41/169 (24) | ||
| Non-smoker | 19/20 (95) | 41/52 (79) | 64/92 (70) | 4/5 (80) | 128/169 (76) | ||
| Phase of menstrual cycle, n/N (%) | 0.13 | 0.52 | |||||
| Luteal | 7/20 (35) | 27/52 (52) | 42/92 (46) | 5/5 (100) | 81/169 (48) | ||
| Follicular | 11/20 (55) | 21/52 (40) | 47/92 (51) | 0/5 (0) | 79/169 (47) | ||
| Unknown | 2/20 (10) | 3/52 (8) | 3/92 (3) | 0/5 (0) | 8/169 (5) | ||
| Contraception, n/N (%) | 0.02 | 0.12 | |||||
| Nil | 15/20 (75) | 18/52 (35) | 29/92 (32) | 1/5 (20) | 63/169 (37) | ||
| Condoms | 1/20 (5) | 10/52 (19) | 16/92 (17) | 0/5 (0) | 27/169 (16) | ||
| COCP | 3/20 (15) | 11/52 (21) | 35/92 (38) | 2/5 (40) | 51/169 (30) | ||
| POP | 0/20 (0) | 4/52 (8) | 4/92 (4) | 0/5 (0) | 8/169 (5) | ||
| Copper IUD | 0/20 (0) | 2/52 (4) | 2/92 (2) | 1/5 (20) | 5/169 (3) | ||
| Mirena IUS | 1/20 (5) | 1/52 (2) | 3/92 (3) | 1/5 (20) | 6/169 (4) | ||
| Vaginal Ring | 0/20 (0) | 0/52 (0) | 2/92 (2) | 0/5 (0) | 2/169 (1) | ||
| Contraceptive implant | 0/20 (0) | 4/52 (8) | 1/92 (1) | 0/5 (0) | 5/169 (3) | ||
| Contraceptive injection | 0/20 (0) | 2/52 (4) | 0/92 (0) | 0/5 (0) | 2/169 (1) | ||
| Time since last intercourse, n/N (%) | 0.20 | 0.60 | |||||
| >48 hours | 16/20 (80) | 49/52 (94) | 77/92 (84) | 5/5 (100) | 147/169 (87) | ||
| <48 hours | 4/20 (20) | 3/52 (6) | 14/92 (16) | 0/5 (0) | 21/169 (13) | ||
COCP: Combined oral contraceptive pill; HSIL: High-grade Squamous intraepithelial lesion; IUD: Intrauterine device; IUS: Intrauterine system; LSIL: Low-grade squamous intraepithelial lesion; NR: not relevant; POP: Progesterone-only pill; SD: standard deviation. P-value calculated using Fishers exact test, Q-value calculated using Benjamini-Hochberg false discovery rate (FDR) method.