Figure 7. Imipramine rescued depressive behaviors and reversed biochemical changes.

After mice in the SIR group were treated with imipramine (20 mg/kg) for 14 days, the immobility time in tail suspension test (A) and forced swimming test (B) were determined. The body weight in different group mice was recorded (C). The content of 5-HT was detected by HPLC (D). The concentration of serum cortisol was determined by ELISA (E). *P < 0.05 versus SIR + NS group. N = 4–6.