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. 2015 Nov 17;5:16285. doi: 10.1038/srep16285

Table 3. Investigation of 2β-Chloropodophyllotoxins (8a–c) Reacting with NCS or NBS.

Entry Compound Amount of NCS orNBS T[°C] t[h] Isolated yield [%]
1 8a NCS (1.1 equiv) 25 24 7a (0)
2 8a NCS (1.1 equiv) 30 7 7a (35) + 7b (15)
3 8a NCS (1.1 equiv) 40 4 7a (54) + 7b (12)
4 8a NCS (1.1 equiv) 50 4 7a (40) + 7b (7)
5 8a NCS (2.2 equiv) 40 11 7b (52)
6 8a NBS (1.1 equiv) 25 24 7c (0)
7 8a NBS (1.1 equiv) 40 5 7c (50)
8 8b NCS (1.1 equiv) 40 48 7a (12)
9 8b NCS (1.1 equiv) 60 24 7a (94) + 7b (trace)
10 8b NCS (2.2 equiv) 60 17 7b (87)
11 8b NBS (1.1 equiv) 60 24 7c (91)
12 8c NCS (1.1 equiv) 40 19 7a (34) + 7b (25)