Table 3.
The comparisons of genotypes and allele frequency distribution of VEGF genetic polymorphisms (−2578C>A, −634C>G and 936C>T) between case group (TOF group) and control group (healthy controls).
| Genotype | TOF patients (n=160) | Healthy controls (n=240) | OR (95%CI) | χ2 | P value |
|---|---|---|---|---|---|
| −2578C>A | |||||
| CC | 10 (6.2%) | 23 (9.6%) | Reference | ||
| CA | 72 (45%) | 138 (57.5%) | 1.20 (0.54–2.66) | 0.202 | 0.653 |
| AA | 78 (48.8%) | 79 (32.9%) | 2.27 (1.01–5.08) | 4.118 | 0.042 |
| AA+CA | 150 (93.8%) | 217 (90.4%) | 1.59 (0.74–3.44) | 1.409 | 0.235 |
| C allele | 92 (28.8%) | 184 (38.3%) | Reference | ||
| A allele | 228 (71.2%) | 296 (61.7%) | 1.54 (1.14–2.09) | 7.803 | 0.005 |
| −634C>G | |||||
| CC | 13 (8.1%) | 29 (12.0%) | Reference | ||
| CG | 61 (38.1%) | 123 (51.3%) | 1.11 (0.54–2.28) | 0.075 | 0.784 |
| GG | 86 (53.8%) | 88 (36.7%) | 2.18 (1.06–4.47) | 4.651 | 0.031 |
| GG+CG | 147 (91.9%) | 211 (81.9%) | 1.55 (0.78–3.09) | 1.601 | 0.206 |
| C allele | 87 (27.2%) | 181 (37.7%) | Reference | ||
| G allele | 233 (72.8%) | 299 (62.3%) | 1.62 (1.19–2.21) | 9.540 | 0.002 |
| 936C>T | |||||
| CC | 73 (45.6%) | 89 (37.1%) | Reference | ||
| CT | 20 (12.5%) | 20 (8.3%) | 1.22 (0.61–2.44) | 0.315 | 0.575 |
| TT | 67 (41.9%) | 131 (54.6%) | 0.62 (0.41–0.96) | 4.723 | 0.030 |
| TT+CT | 87 (54.4%) | 151 (62.9%) | 1.42 (0.96–2.14) | 2.907 | 0.088 |
| C allele | 166 (51.9%) | 198 (41.3%) | Reference | ||
| T allele | 154 (48.1%) | 282 (58.7%) | 0.65 (0.49–0.87) | 8.741 | 0.003 |
TOF – tetralogy of Fallot; OR – odds ratio; 95%CI – 95% confidence interval.