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. 2015 Apr 27;36(7):800–812. doi: 10.1038/aps.2015.9

Table 2. Inhibition of ACh-evoked nAChR subtype and serotonin-evoked 5-HT3A currents by Br-IQ17B in TEVC.

Target IC50 (nmol/L) n
α7, Human 28.5±2.5 vs 100 μmol/L ACh 6
α4β2, Rat >100 000 vs 100 μmol/L ACh 6
α3β4, Rat 381 510±52 251 vs 300 μmol/L ACh 5
5-HT3A, Human 3740±90 vs 10 μmol/L 5-HT 6