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(A) The time course of Caco-2 cell uptake of imperialine (n=3): cP<0.01, compared with 1 h; (B) The effect of pH on imperialine in Caco-2 cell uptake (n=3). cP<0.01, compared with the pH 7.4 group; (C) The effect of concentration on imperialine in Caco-2 cell uptake (n=3); (D) The effect of temperature on imperialine in Caco-2 cell uptake (n=3): bP<0.05; (E) The effect of the P-gp or NPC1L1 transporter inhibitor on Caco-2 cell uptake (n=3).
