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. 2015 Apr 21;18(10):pyv046. doi: 10.1093/ijnp/pyv046

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© The Author 2015. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — The body weight (A) and sucrose preference (B) of rats in the 4 groups during 8 weeks. Chronic unpredicted mild stress (CUMS) significantly reduced the increase of rats’ body weight after 2 weeks of stress (P=.0046, n=24/group), and the influence remained to the end of experiment (P<.0001, n=12/group). However, chronic escitalopram administration did not affect the body weight in both stressed and control animals (A). After 3 weeks of initial exposure to CUMS, sucrose preference was significantly decreased in stressed rats compared with controls (P=.0002, n=24/group), and the difference continued to the end of experiment at week 8 (the normal rats with saline treatment [NS] group vs the CUMS with saline treatment subgroup (CS) group, P<.0001, n=12/group). After 3 weeks of escitalopram treatment, the sucrose preference of rats in the CUMS with escitalopram treatment subgroup (CE) group was significantly increased compared with that of the CS group (P=.0473). The significance increased further at the end of experiment for the CE group compared with the CS group (P=.0157). **P<.05 and ****P<.0001, the differences in body weight between control and stressed rats. Error bars represent SEM.