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. 2015 Apr 21;18(10):pyv045. doi: 10.1093/ijnp/pyv045

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© The Author 2015. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Effects of citalopram on hippocampal extraneuronal levels of 5-HT, dopamine (DA), and noradrenaline (NA) from hippocampi of HDC^+/+ and HDC^-/- mice. (A) Neurotransmitter extraneuronal levels were measured in fractions collected every 30 minutes. Baseline values were determined from the average of 4 samples preceding citalopram infusion, which was begun at time 120 and terminated at time 180. No significant differences were observed between HDC^+/+ and HDC^-/- mice. Citalopram significantly increased the extraneuronal levels of 5-HT in the hippocampus of both genotypes, but not of DA or NA. The mean basal extraneuronal level of 5-HT was 69±15fmol/30min in HDC^-/- mice (n=8) and 77±11fmol/30min in HDC^+/+ mice (n=8). The mean of the DA basal extraneuronal level was 68±5fmol/30min in HDC^-/- mice (n=6) and 67±7fmol/30min in HDC^+/+ mice (n=6). The mean of the NA extraneuronal level was 17±5fmol/30min in HDC^-/- mice (n=6) and 15±5fmol/30min in HDC^+/+ mice (n=6). Represented are means ± SEM of 6 to 8 mice. ***P<.001 from “citalopram” and “cortical methysergide + citalopram” (2-way ANOVA and Bonferroni test).