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. 2015 Apr 21;18(10):pyv045. doi: 10.1093/ijnp/pyv045

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© The Author 2015. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Effects of citalopram on hypothermic response induced by 8-Hydroxy-2-(di-n-propylamino)tetralin hydrobromide (8-OH-DPAT) in HDC^+/+ and HDC^-/- mice. 8-OH-DPAT (1mg/kg, s.c.) similarly decreased body temperature in HDC^+/+ and HDC^-/- mice. A single administration of citalopram 30 minutes prior to 8-OH-DPAT injection attenuated hypothermic response elicited by the prototypical agonist in both genotypes. Moreover, citalopram failed to affect basal temperature. Represented are means ± SEM of 6 to 7 mice. ***P<.001 from basal temperature of the same group; ^# P<.05, ^## P<.01 from saline of corresponding genotype (2-way ANOVA and Bonferroni test).