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. 2015 Apr 21;18(10):pyv045. doi: 10.1093/ijnp/pyv045

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© The Author 2015. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Effects of citalopram on cortical histamine (HA) extraneuronal levels of freely moving, CD1 mice. Citalopram significantly increased HA extraneuronal levels immediately after its administration (n=6). Systemic administration of methysergide prevented citalopram-elicited increase of HA extraneuronal levels (n=4), but not when administered in the cortex (n=3). The arrow indicates the time of citalopram administration. Baseline HA extraneuronal levels were not detectable in alpha-fluoromethylhistidine (α-FMHis)–treated mice. In these animals, HA extraneuronal levels were not detectable also during citalopram administration (dashed line; n=3). Represented are means ± SEM. ** P<.05, ***P<.001 vs “citalopram” and “methysergide (cortical) + citalopram”. Two-way ANOVA and Bonferroni’s test.