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. 2015 Apr 21;18(10):pyv045. doi: 10.1093/ijnp/pyv045

Figure 6.

Figure 6.

Citalopram-induced CREB phosporylation is absent in histamine (HA)-deprived mice. (A) Subchronic administrations of citalopram (3×10mg/kg, i.p. in 24 hours) increased the phosphor-CREB (pCREB)/CREB ratio in the hippocampus of HDC+/+ but not of HDC-/- mice, as shown by Western-blot analysis. Shown are means ± SEM of 6 to 10 animals for each group; *P<.05, ##P<.01 vs citalopram-treated HDC+/+ mice. (B) Administration of 8-bromoadenosine 3’, 5’-cyclic monophosphate (8-Br-cAMP; i.c.v., 5 µg/5 µL 30 minutes prior to sacrifice) increased the pCREB/CREB ratio in the hippocampus of mice of both genotypes. Shown are means ± SEM of 4 to 5 mice per group (*P<.05, vs 8-Br-cAMP-treated mice, ANOVA, and Newman-Keuls post-hoc test). (C) Administration of 8-Br-cAMP significantly reduced immobility of mice of both genotypes in the tail suspension test (TST) (*P<.05 vs saline-treated mice; n=8–9/group).