Table 1. Approaches for the regulation of alternative splicing as a potential therapy.

	Approaches	Examples/targeted genes	References
Small molecule	Targeting protein isoforms	Etoricoxib/COX2	35
	Targeting expression	Aclarubicin/SMA	36
	Targeting trans-acting element	Toyocamycin/XBP1	37
Antisense oligonucleotide-mediated regulation		tDNA-AONs/DMD	38,39
RNAi-based isoform specific modulation		SMaRT/MAPT	40