. 2015 Sep 21;36(10):1219–1227. doi: 10.1038/aps.2015.92

Table 1. Intra-tumor heterogeneity in different cancer types.

Cancer type	Types of heterogeneity	Reference(s)
Brain	Mutations, amplifications and expressions of genes related to oncogenic signaling, proliferation, immune response and hypoxia, CD133 expression	^{8,9,18,31,33,40}
Renal	Mutations, chromosome aberrations, DNA ploidy	¹⁰
Breast	Cell surface marker expressions, genotypic alterations	^{11,12,13,16,41,42}
Leukemia	Expressions of multiple cell surface markers, Ki-67, Bcl-2, cyclin D, cyclin E and RAS, phosphorylations of signaling proteins	^{14,23,24,25,26,27,28,30,35,36,37}
Colorectal	CD133 and receptor tyrosine kinase expressions, phosphorylations of signaling proteins	^19,20,34,43
Melanoma	Expressions of multiple cell surface markers and cytoplasmic proteins	^21,22,44,45
Lung	DNA ploidy, EGFR and BRAF V600E mutations, p53, c-Myc and Ki-67 expressions, phosphorylations of signaling proteins	^29,31,38,46
Sarcoma	O-glycosylation of MT1-MMP	³⁹
Head and neck	Genotypic alterations	⁴⁷