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. 2015 Nov 17;8(11):e002569. doi: 10.1161/CIRCINTERVENTIONS.115.002569

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© 2015 The Authors.

Circulation: Cardiovascular Interventions is published on behalf of the American Heart Association, Inc., by Wolters Kluwer. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 4. — Experimental study hemodynamics. A, Mean pulmonary artery pressure (mPAP) at baseline and maximum thromboxane A₂ agonist (TxA₂) pre (TxA₂-1) and post (TxA₂-2) procedure for sham- and pulmonary artery denervation (PDN)-treated animals. B, Area under the curve (AUC) of time–pressure for PDN- and sham-treated animals during the pre and post procedure TxA₂ challenges, cardiac output (CO; C), pulmonary vascular resistance (PVR; D), LVSP (E), and LVEDP (F) at baseline and maximum TxA₂ pre and post procedure for sham- and PDN-treated animals. PDN, n=5; Sham, n=3; mean±SEM. LVEDP indicates left ventricular end diastolic pressure; and LVSP, left ventricular systolic pressure. *P<0.05, **P<0.01, 2-way ANOVA with Sidak’s correction for multiple comparisons.