Figure 1.

Kaplan–Meier survival curves of wild-type, knockout, and transgenic mice. Vertical bars indicate a censoring event (usually representing killing of an animal for experimental purposes). Mean survival times were significantly decreased for Gα_i2^−/− and β₁-tg/Gα_i2^−/− mice, each compared with all other genotypes. However, compared with Gα_i2^−/− mice, survival time was significantly lower in β₁-tg/Gα_i2^−/− mice (log-rank test). The number of animals underlying survival analysis was 200, 34, 37, and 192 for wild-type (C57BL/6), Gα_i2^−/−, β₁-tg/Gα_i2^−/−, and β₁-tg mice, respectively. Vertical dashed lines label age range of mice used for further investigations (Figures 2, 3, 5–7).