Figure 6.

Expression of cardiac hypertrophy markers in murine ventricles. Increased mRNA expression of ANP (A) and BNP (B) compared with wild-type levels confirmed morphological parameters indicating cardiac hypertrophy in β₁-tg/Gα_i2^−/− mice. The number of animals used for analysis was 3–4 for each genotype. Age range of examined mice was 302 ± 4 days. Asterisks indicate significant differences compared with mRNA expression levels of age-matched wild-type mice in an REST^® analysis (*P < 0.05, **P < 0.01).