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. Author manuscript; available in PMC: 2015 Nov 17.
Published in final edited form as: Antiviral Res. 2014 Jun 16;108:148–155. doi: 10.1016/j.antiviral.2014.06.001

Figure 1.

Figure 1

Mean ± SEM papilloma size of wtCRPV induced left-side (L) papillomas treated with compound (●) or right-side (R) papillomas that were untreated (▼); mE8-CRPV induced papillomas treated with compound (○) or untreated (▽). Each point represents weekly measurements of 4 papillomas on 4 rabbits (cidofovir treatments) or 2 papillomas on 2 rabbits (formulations without cidofovir). Topical treatments began at day 19, and were daily applications for 5 days per week. Treatments were 1% cidofovir in saline (A), 1% cidofovir in 10% DMSO (B), 1% cidofovir in Carbomer 940 (C), 1% cidofovir in cremophor (D), cremophor alone (E) and carbomer 940 alone (F). Statistics (p<0.05 marked with asterisk): (Graphs A, B, E and F) no significant differences; (Graph C) Mann-Whitney Rank Sum test p<0.05 for L2 versus R2, week 8; (Graph D) Mann-Whitney Rank Sum test p<0.05 for L1 versus R1, weeks 5-8, and Mann-Whitney Rank Sum test p<0.05 L2 versus R2, week 7.