Table 1.

Proportions of positive newborn screens for metabolic disorders in HIV screen-positive and HIV screen-negative neonates in New York State (2005–2008).

POSITIVE NBS FOR:	HIV NBS + (N=2371)	HIV NBS − (N=1,003,954)	P value
Any metabolic disorder	53 (2.2%)	11,949 (1.2%)	2.5 × 10−5
Mitochondrial metabolic disorder*	42 (1.8%)	8118 (0.8%)	5.0 × 10−6
Urea cycle disorder	3 (0.1%)	1310 (0.1%)	0.99
Organic Acidemia	14 (0.6%)	1220 (0.1%)	2.2 × 10−6
Fatty acid oxidation disorder†	20 (1.0%)	4130 (0.4%)	0.001
MCADD/MADD	5 (0.2%)	923 (0.09%)	0.07
CPT1/2	8 (0.3%)	471 (0.05%)	2.3 × 10−5
Carnitine deficiency	9 (0.4%)	1869 (0.2%)	0.05
Amino acid disorder	11 (0.5%)	3831 (0.4%)	0.5
PKU	8 (0.3%)	1027 (0.1%)	0.004
MSUD	1(0.04%)	916 (0.09%)	0.65
Tyrosinemia	1(0.04%)	497 (0.04%)	0.76
Homocystinuria	1(0.04%)	900(0.03%)	0.67

^*Includes Urea cycle disorders, Organic acidemias, Fatty acid oxidation disorders.

^†Two newborns were positive for both MCADD/MADD and CPT1/2. NBS, Newborn screen; MCADD, Medium chain acyl-CoA dehydrogenase deficiency; MADD, Multiple acyl-CoA dehydrogenase deficiency (Glutaric aciduria, type 2); CPT, Carntine palmitoyltransferase; PKU, Phenylketonuria; MSUD, maple syrup urine disease.