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General Sortase Isoforms. There are three characterized isoforms of sortase. SrtA is conserved across all Gram-positive bacteria, while SrtB and SrtC have more specialized functions and are only found in select species.
| Sortase Isoform | Recognition Sequence | Function | Pathogenic Species |
|---|---|---|---|
| A | LPXTG | General, “housekeeping” | All Gram-positive bacteria |
| B | NPQTN | Iron deprivation response | Bacilli, Listeria, S. aureus |
| C | QVPTG | Pilin polymerase | Streptococcus, C. diphtheriae, E.faecalis, B. cereus |
