. Author manuscript; available in PMC: 2016 Apr 10.

Published in final edited form as: ACS Infect Dis. 2015 Mar 11;1(4):168–174. doi: 10.1021/acsinfecdis.5b00005

Table 1.

In Vitro Activity of 3 against a Drug-Resistant M. tuberculosis Panel

		MIC (μg/mL)
		3	RMP^a	INH^b	SM^c	KM^d	PA824^e
M. tuberculosis H₃₇Rv	MABA	0.10	<0.08	0.05	0.12	0.65	0.01
M. tuberculosis H₃₇Rv	LORA	0.72	0.85	>13.7	1.10
Drug-resistant M. tuberculosis strains	rRMP	0.27	>2.00	0.02	0.27	0.92	0.03
	rINH	0.13	0.01	>2.00	0.46	0.95	0.03
	rSM	0.17	0.03	0.02	>2.00	0.95	0.11
	rKM	0.06	<0.01	0.03	1.20	>2.00	0.19
	rCS	0.14	<0.01	0.01	0.41	0.98	0.12

RMP, rifampicin.

INH, isoniazid.

SM, streptomycin.

KM, kanamycin.

PA824, experimental nitroimidazole antibiotic. rRMP (ATCC 35838); rINH (ATCC 35822); rSM (ATCC 35820); rCS (cycloserine; ATCC35826); rKM (ATCC 35827).