Added value of genomic to a clinical model predictive of lung cancer. Receiver operating characteristic curves of the combined training and test sets (n=118), consisting of smokers undergoing bronchoscopy for suspicion of lung cancer. The clinical model (······) includes three variables: age, mass size and lymphadenopathy; the clinicogenomic model (——) includes the previous variables and the biomarker score. The area under the curve for the clinical and clinicogenomic models is 0.89 and 0.94, respectively, which represents a significant difference between the two curves (p<0.05). Reproduced from [97], with permission from the publisher.