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. Author manuscript; available in PMC: 2015 Nov 17.
Published in final edited form as: Eur Respir J. 2009 Aug;34(2):489–506. doi: 10.1183/09031936.00042409

FIGURE 5.

FIGURE 5

Relationship between predicted chemotherapeutic sensitivity and oncogenic pathway deregulation. a) Probability of oncogenic pathway deregulation as a function of predicted docetaxel sensitivity in a series of lung cancer cell lines (red: sensitive; blue: resistant). b) Lung cancer cell lines showing an increased probability of phosphoinositide 3-kinase (PI3K) activation were more likely to respond to a PI3K inhibitor (p=0.001, log-rank test), as measured by sensitivity to the drug in cell proliferation assays. c) Furthermore, cell lines predicted to be resistant to docetaxel were more likely to be sensitive to PI3K inhibition (p<0.001, log-rank test). Src: avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homologue; Ras: rat sarcoma viral oncogene homologue; E2F3: E2F transcription factor 3; Myc: myelocytomatosis viral oncogene homologue; IC50: half maximal inhibitory concentration. Reproduced from [180], with permission from the publisher.