Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Sep 26;25(10):1073–1188. doi: 10.1002/hipo.22488

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 The Authors Hippocampus Published by Wiley Periodicals, Inc.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

PMC Copyright notice

Prolongation and truncation of ripples. (A–E) Perievent histograms of ensemble spiking activity of interneurons (INT, blue) and pyramidal neurons (PYR, red; mean ± SEM) during spontaneous SPW‐Rs (A) and optogenenetic closed‐loop stimulation (C–E). (B) Ripples are detected in real‐time about three cycles after onset, and the detection triggers light stimulation. (C) Ripple‐contingent activation of pyramidal cells drives PYR and increases duration of spontaneously occurring ripples. Example wide‐band trace shows a single event. (D) Direct silencing of pyramidal cells shortens spontaneously occurring ripples. (E) Indirect silencing of pyramidal cells via PV interneuron activation shortens ripples. After Stark et al. (2014).