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. 2015 Sep 26;25(10):1073–1188. doi: 10.1002/hipo.22488

Figure 52.

Figure 52

Conversion of SPW‐Rs to p‐ripples may be separated by an asynchronous transition epoch. (A) Time‐binned autocorrelogram of multi‐unit activity showing that the synchrony of firing during SPW‐Rs, transition period and preictal p‐ripples (24 min sweep). Epileptiform event was induced by high K+ in vitro. (B) Abolishing SPW‐Rs in vivo by local infusion of picrotoxin (PTX) and induction of p‐ripples. Note long transition period of no‐SPW‐Rs at 50s. Both SPW‐Rs and fast p‐ripples were induced by focal light stimulation of CA1 pyramidal cells in a CaMKII::ChR2 mouse. Panels show the time‐frequency decomposition of the pyramidal layer CSD traces. (C) LFP traces at different depths across the CA1 pyramidal layer at 50 µm steps (grey lines) and current source density (color maps) of average SPW‐Rs (100 ms sweep) and PTX‐induced p‐ripples (50 ms sweep). (A) Reproduced from Karlocai et al., 2014; (B, C) Reproduced from Stark et al., 2014.