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. 2015 Mar 29;17(11):1486–1496. doi: 10.1093/neuonc/nov045

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© The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Fig. 4. — Supratentorial (ST) and infratentorial (IT) pilocytic astrocytomas (PAs) exhibit different molecular patterns. (A) Principal components analyses (PCA) comparing ST and IT pediatric low-grade gliomas (PLGGs) and (B) ST and IT PAs. (C) Heat map of genes found to be differentially expressed between ST and IT PAs. (D) Enrichment plot of an IL12 gene set found to be significantly enriched in ST PAs relative to IT PAs. (E) HLA-DRA immunohistochemical staining of individual ST and IT PAs (top) and summary results across 8 ST and 8 IT tumors (bottom). The Y-axis represents the area under the curve (AUC) metric from Cell Profiler. *P < .05.