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. 2015 May 24;17(11):1453–1462. doi: 10.1093/neuonc/nov090

Fig. 1.

Fig. 1.

CD40/CD40L gene expression and immunohistochemistry in glioma tissues. (A) CD40 gene expression analyzed by quantitative PCR in glioma tissues. Expression of CD40 was significantly higher in 36 cases of grade III gliomas than in 86 cases of grade IV glioblastomas (GBM) (*P = .0334). (B) Representative immunohistochemical image of CD40 in GBM tissues that revealed the high expression of CD40 by quantitative PCR. CD40-positive GBM cells were detected. Scale bar, 100 μm. (C) CD40L gene expression analyzed by quantitative PCR. Expression of CD40L was significantly higher in grade III gliomas than in grade IV GBM (*P< .0001). (D) Representative immunohistochemical image of CD40L in GBM tissues that revealed the high expression of CD40L by quantitative PCR. CD40L-positive GBM cells were detected. Scale bar, 100 μm.