Table 4.
Multivariable Cox models for (a) VASARI and volumetric features, (b) quantitative and qualitative imaging features in patients with glioblastoma, and (c) age- and KPS-adjusted multivariable Cox model for imaging features in patients with glioblastoma
| Overall Survival |
Progression-free Survival |
|||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| VASARI features model | ||||
| T1/FLAIR ratio (infiltrative/mixed vs expansive) | 1.64 (1.04–2.6) | .03 | ||
| Ependymal extension (yes vs no) | 1.74 (1.11–2.73) | .02 | ||
| Deep white matter invasion (yes vs no) | 1.89 (1.20–2.97) | .006 | 1.95 (1.20–3.16) | .007 |
| Distribution (multifocal and multicentric vs focal) | 3.6 (1.54–8.43) | .003 | ||
| Volumetric features model | ||||
| Tumor proportion | 17.21 (2.42–122.55) | .004 | ||
| Edema volume (higher vs lower than 85 000 mm3) | 2.09 (1.29–3.39) | .003 | ||
| Tumor volume (higher vs lower than 24 850 mm3) | 1.61 (1.00–2.60) | .050 | ||
| Quantitative and qualitative imaging features | ||||
| Tumor volume (higher vs lower than 35 000 mm3) | 1.74 (1.06–2.86) | 0.03 | ||
| Eloquent brain (eloquent vs noneloquent) | 2.92 (1.72–4.95) | <0.001 | ||
| Deep white matter invasion (yes vs no) | 1.90 (1.15–3.16) | .01 | ||
| Distribution (multifocal and multicentric vs focal) | 2.16 (0.94–4.97) | .07 | ||
| Age- and KPS-adjusted multivariable Cox model | ||||
| Tumor (higher vs lower than 35 000 mm3) | 1.79 (0.94–3.42) | 0.08 | ||
| Eloquent brain (eloquent vs noneloquent) | 2.44 (1.28–4.65) | 0.007 | ||
| Deep white matter invasion (yes vs no) | 1.78 (1.03–3.07) | .04 | ||
| Distribution (multifocal and multicentric vs focal) | 2.07 (0.83–5.15) | .11 | ||