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. 2015 Mar 27;22(11):1742–1753. doi: 10.1038/cdd.2015.20

Figure 5.

Figure 5

Activation of SIRT1 normalizes locomotor deficits in Abcd1−/Abcd2−/− mice. (a and c) Treadmill test was carried out in (a) 18-month-old WT (n=12), Abcd1−/Abcd2−/− (n=17) and Abcd1−/Abcd2−/− mice treated with RSV (Abcd1−/Abcd2−/−+RSV) (n=12) and in (c) WT (n=20), Abcd1−/Abcd2−/−(n=20) and Abcd1−/Abcd2−/− mice with transgenic overexpression of SIRT1 (Abcd1−/Abcd2−/−/SIRT1Tg) (n=16). The latency to falling off the belt (time of shocks) and the number of shocks received were computed after 7 min. (b and d) Bar-cross test was carried out in (b) 18-month-old WT (n=12), Abcd1−/Abcd2−/− (n=17) and Abcd1−/Abcd2−/− mice treated with RSV (Abcd1−/Abcd2−/−+RSV) (n=12) and in (d) WT (n=20), Abcd1−/Abcd2−/−(n=20) and Abcd1−/Abcd2−/− mice with transgenic overexpression of SIRT1 (Abcd1−/Abcd2−/−/SIRT1Tg) (n=16). The time spent to cross the bar and the numbers of slips were quantified. Values are expressed as mean±S.D. (*P<0.05, **P<0.01 and ***P<0.001, one-way ANOVA followed by Tukey's HSD post hoc)