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. 2015 Mar 27;22(11):1775–1784. doi: 10.1038/cdd.2015.23

Figure 5.

Figure 5

Blockade of either Akt or Ccnd1 activity confers neuroprotection comparable to the RBPJK loss. (a) Scheme depicting the strategy and time course of pharmacological treatment with SC-66 and PD 0332991. (b) Graph summarizing the counts of condensed nuclei in hippocampal CA fields upon application of an Akt (SC-66; n=3 mice per condition) and a Ccnd1 (PD 0332991; n=4 mice per condition) inhibitor following KA challenge. (c) Flow chart summarizing the proposed pathway involving Notch, Akt, Ccnd1 and E2F1 leading to cell cycle reentry in neurons. Error bars represent mean±S.E.M.