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. 2015 Apr 17;22(11):1837–1845. doi: 10.1038/cdd.2015.38

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Loss of Idh1 exacerbates LPS-induced liver injury. (a) Quantitation of serum levels of (top) AST and (bottom) ALT in Idh1 KO and WT mice that received a sublethal LPS dose. Blood samples were collected at 6 h after LPS injection. Data are expressed as the fold change relative to values in LPS-treated WT mice and are the mean±S.D. (n=6). *P<0.05. (b) TUNEL staining of apoptotic cells in the livers of the mice in (a), which were killed at 12 h after LPS injection. Top: TUNEL staining; bottom: DAPI (4',6-diamidino-2-phenylindole). Magnification × 10. Quantitation of apoptotic cells in the livers was shown on the right. Data were collected as described in Materials and Methods and are the mean percentage of TUNEL⁺ cells±S.D. *P<0.05